Scientists for the first time have recognized compounds in coffee that might be causing prostate cancer. The study has been conducted on mice, but not on humans so far.
The first author of the study, Dr. Hiroaki Iwamoto said that they had found that the kahweol acetate and cafestol repressed the growth of cancer cells in mice, however, the combination worked synergistically, resulting in much slower tumor growth than in the untreated mice. He said that after 11 days, the tumors that were untreated had grown roughly 3 and a half times the original volume (342%), however, the tumors in the treated mice with both the compounds had grown more than roughly one and a half (167%) times their original size. He further added that It was important to keep the findings in a perspective. As it was a pilot study, so the work showed that the utilization of these compounds was feasible but needed further investigation and so it did not mean that the findings could be applied to humans.
Professor at the ‘Department of Integrative Cancer Therapy and Urology’, Mr. Atsushi Mizokami added: “These are promising findings, but they should not make people change their coffee consumption. Coffee can have both positive and negative effects (for example it can increase hypertension), so we need to find out more about the mechanisms behind these findings before we can think about clinical applications. However, if we can confirm these results, we may have candidates to treat drug-resistant prostate cancer.”
Professor of the Experimental Urology, Mr, Zoran Culig, commented: “These are interesting findings. I would expect that those initial results will motivate researchers to use more recently developed models, such as patient-derived xenografts which express the androgen receptor. Such experiments will likely provide a definitive answer as to the future perspective of this kind of treatment.”