Treatment Target could be served by Opioid Addiction Mechanism

Treatment Target could be served by Opioid Addiction Mechanism.

A team from Scripps analysis says it’s discovered a molecular method in brain cells which will be a serious driver of drug addiction, and therefore might become a target for future addiction treatments.

A team from Scripps analysis says it’s discovered a molecular method in brain cells which will be a serious driver of drug addiction, and therefore might become a target for future addiction treatments.

The scientists, who revealed their article (“Allostatic Changes within the cAMP System Drive Opioid-Induced Adaptation in Striatal Intropin Signaling”) in Cell Reports, used a complicated imaging technique to see nerve cell activity throughout exposure to opioid during a part of the brain—the nucleus accumbens—known to be centrally necessary for addiction. They found that key brain-cell changes that occur with addiction and facilitate sustain addiction behavior are in the midst of, and probably driven by, specific changes during a communication system involving cyclic AMP (cAMP).

“Opioids are powerful addictive agents that alter dopaminergic influence on reward communication in medium setose neurons (MSNs) of the nucleus accumbens. Recurrent opioid exposure triggers adaptive changes, shifting reward valuation to the allostatic state underlying tolerance. However, the cellular substrates and molecular logic underlying such allostatic changes don’t seem to be well understood,” the investigators wrote.

“Here, to report that the malleability of dopamine-induced cyclic AMP (cAMP) communication in MSNs is a cellular substrate for drug-induced allostatic changes. By recording cAMP responses to optically elicited Intropin in brain slices from mice subjected to numerous opioid exposure paradigms, we tend to outline profound neuronal-type-specific diversifications. We discover that opioid exposure pivots the initial hyper-responsiveness of D1-MSNs toward D2-MSN dominance as dependence escalates.